• Molecular and cellular immunopathogenesis of vector-borne viral diseases 

   (e.g., flaviviruses, severe fever with thrombocytopenia syndrome virus, Chikungunya virus)

• Innate and adaptive immune responses to genital and respiratory viral infections 

   (e.g., herpesvirus, influenza virus, SARS-CoV-2)

• Molecular and cellular immunopathogenesis underlying exacerbation of viral infections in the presence of underlying diseases

• PhD : College of Pharmacy, Chungbuk National University, Korea

• MS : Korea Advanced Institute of Science and Technology (KAIST), Korea

• BSc : College of Pharmacy, Chungbuk National University, Korea

• 1991–1995: Research Scientist, LG Biotech Institute, Daejeon, Korea

• 1998: Research Associate, Division of Oncogenic Virology, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Korea

• 1998–2001: Research Associate, Department of Microbiology, University of Tennessee, Knoxville, USA

• 2002–present: Professor, Laboratory of Microbiology, College of Veterinary Medicine, Jeonbuk National University, Korea

• 2002: Visiting Scientist, Department of Microbiology, University of Tennessee, Knoxville, USA

• 2016–2017: Visiting Scholar, University of California, San Diego (UCSD), USA — Research on the molecular role of macrophages in colitis and asthma

• 2013–2015: Director, Bio-Safety Research Institute, Jeonbuk National University (https://biosafety.jbnu.ac.kr)

• 2018–2020: Dean, College of Veterinary Medicine, Jeonbuk National University

• 2021–present: Director, Core Facility Center of Zoonosis Research, Jeonbuk National University (funded by the National Research Foundation of Korea)

• Choi JY, Byeon HW, Park SO, Uyangaa E, Kim K, Eo SK. Inhibition of NADPH oxidase 2 enhances resistance to viral neuroinflammation by facilitating M1 polarization of macrophages in extraneural tissues. Journal of Neuroinflammation 21:115 (2024).

• Lee Y, Seo M, Yun SH, Yu M, Kim HJ, Cho HW, Byeon HW, Park SO, Uyangaa E, Jeon H, Lee M, Kwon YD, Eo SK. Inhibitory peptides derived from Hepatitis C virus NS5A for reducing clinical symptoms of dengue virus infection. Antiviral Research 231:106018 (2024).

• Jeong JS, Choi JY, Kim JS, Park SO, Kim W, Yoon YG, Park HJ, Park KH, Kim DH, Kim JM, Koh GY, Eo SK, Lee YC. SARS-CoV-2 infection in severe asthma is associated with worsening of COVID-19 through respiratory NLRP3 inflammasome activation. Allergy 78:287–290 (2023).

• Patil AM, Choi JY, Park SO, Uyangaa E, Kim B, Kim K, Eo SK. Type I IFN signaling limits hemorrhage-like disease after infection with Japanese encephalitis virus by modulating prerequisite infection of CD11b+Ly-6C+ monocytes. Journal of Neuroinflammation 18:136 (2021).

• Choi JY, Kim JH, Hossain FMA, Uyangaa E, Park SO, Kim B, Kim K, Eo SK. Indispensable role of CX3CR1+ dendritic cells in regulating virus-induced neuroinflammation through rapid development of antiviral immunity in peripheral lymphoid tissues. Frontiers in Immunology 10:1467 (2019).

• Kim JH, Patil AM, Choi JY, Kim SB, Uyangaa E, Hossain FM, Park SY, Lee JH, Eo SK. CCR5 ameliorates Japanese encephalitis by dictating the equilibrium of regulatory CD4+Foxp3+ T cells and IL-17+CD4+ Th17 cells. Journal of Neuroinflammation 13:223 (2016).

• Uyangaa E, Kim JH, Patil AM, Choi JY, Kim SB, Eo SK. Distinct upstream role of Type I IFN signaling in hematopoietic stem cell-derived and epithelial resident cells for recruitment of Ly-6Chi monocytes and NK cells via the CCL2–CCL3 cascade. PLoS Pathogens 11:e1005256 (2015).

• Kim SB, Choi JY, Kim JH, Uyangaa E, Patil AM, Park SY, Lee JH, Kim K, Han YW, Eo SK. Amelioration of Japanese encephalitis by blocking 4-1BB signaling is coupled to divergent enhancement of type I/II IFN responses and Ly-6Chi monocyte differentiation. Journal of Neuroinflammation 12:216 (2015).

• Han YW, Choi JY, Uyangaa E, Kim SB, Kim JH, Kim BS, Kim K, Eo SK. Distinct regulation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signaling pathways. PLoS Pathogens 10:e1004319 (2014).

• Aleyas AG, Han YW, Patil AM, Kim SB, Kim K, Eo SK. Impaired cross-presentation of CD8α+CD11c+ dendritic cells by Japanese encephalitis virus in a TLR2/MyD88-dependent manner. European Journal of Immunology 42(10):2655–2666 (2012).

• Rahman MM, Uyangaa E, Han YW, Kim SB, Kim JH, Choi JY, Eo SK. Oral co-administration of live attenuated Salmonella enterica serovar Typhimurium expressing chicken interferon-α and interleukin-18 enhances protection against avian influenza virus H9N2. Veterinary Microbiology 157(3–4):448–455 (2012).

• Aleyas AG, Han YW, George JA, Kim B, Kim K, Lee CK, Eo SK. Multifront assault on antigen presentation by Japanese encephalitis virus subverts CD8+ T cell responses. Journal of Immunology 185(3):1429–1441 (2010).

• Aleyas AG, George JA, Han YW, Rahman MM, Kim SJ, Han SB, Kim BS, Kim K, Eo SK. Functional modulation of dendritic cells and macrophages by Japanese encephalitis virus through MyD88 adaptor molecule- dependent and -independent pathways. Journal of Immunology 183(4):2462–2474 (2009).