전북대학교
2024
1. Xiaohui Yang, Dohyeon Lee, Hyun-Woo Kim, Byung-Hyun Park, Changjin Lim*, and Eun Ju Bae* Cannabidiol inhibits IgE-mediated mast cell degranulation and anaphylaxis in mice. Mol. Nutr. Food Res. 68:2300136 (2024).
2. Hwang Chan Yu, Yong Geun Jeon, Ann Yae Na, Chang Yeob Han, Mi Rin Lee, Jae Do Yang, Hee Chul Yu, Jung Beom Son, Nam Doo Kim, Jae Bum Kim, Sangkyu Lee*, Eun Ju Bae*, and Byung-Hyun Park* PAK4 counteracts PKA dependent lipolysis by phosphorylating FABP4 and HSL. Nat. Metab. 6(1): 94-112 (2024).
2023
1. Min Yan Shi, Hwang Chan Yu, Chang Yeob Han, In Hyuk Bang, Ho Sung Park, Kyu Yun Jang, Jeong Bum Son, Nam Doo Kim, Byung-Hyun Park*, and Eun Ju Bae* p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1. Nat. Commun. 14: 4987 (2023).
2. Mi-Ra Oh, Su-Jin Jung, Soo-Wan Chae, Byung-Hyun Park*, and Seung-OK Lee* Lycium chinense Miller fruit extract lowers serum liver enzymes in subjects with mild hepatic dysfunction: A randomized, double-blinded, placebo-controlled clinical trial. Eur. J. Nutr. 62(3): 1415-1425 (2023).
3. Eun Ju Bae* and Byung-Hyun Park* Multiple roles of sirtuin 6 in adipose tissue inflammation. Diabetes Metab. J. 47(2):164-172 (2023).
4. Oh Kwang Kwon, In Hyuk Bang, So Young Choi, Ju Mi Jeon, Ann Yae Na, Gao Yan, Sam Seok Cho, Sung Hwan Ki, Youngshik Choe, Jun Nyung Lee, Yun-Sok Ha, Eun Ju Bae, Tae Gyun Kwon*, Byung-Hyun Park*, and Sangkyu Lee* SIRT5 is the desuccinylase of LDHA as a novel cancer metastatic stimulator in aggressive prostate cancer. Genom. Proteom. Bioinf. 21(1):177-189 (2023).
2022
1. Yuancheng Mao, Eun Lee, Xiaohui Yang, Eun Ju Bae*, Raok Jeon*, and Byung-Hyun Park* Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischemia-reperfusion injury in mice. J. Enzym. Inhib. Med. Chem. 37(1):2133-2146 (2022).
2. Yong Gyun Lee, Hayoung Woo, Chul Choi, Ga-Hee Ryoo, Yun-Jo Chung, Ju-Hyung Lee, Su-Jin Jung, Soo-Wan Chae, Eun Ju Bae* and Byung-Hyun Park* Supplementation with Vitis vinifera Jingzaojing leaf and shoot extract improves exercise endurance in mice. Nutrients 14:4033 (2022).
3. Yong Gyun Lee, Mi-Young Song, Hwangeui Cho, Jong Sik Jin, Byung-Hyun Park* and Eun Ju Bae* Limonium tetragonum promotes running indurance in mice through mitochondrial biogenesis and oxidative fiber formation. Nutrients 14:3904 (2022).
4. Yuancheng Mao, Chang Yeob Han, Lihua Hao, Younho Lee, Jung Beom Son, Hwangeun Choi, Mi Rin Lee, Jae Do Yang, Suk Kyun Hong, Kyung-Suk Suh, Hee Chul Yu, Nam Doo Kim*, Eun Ju Bae*, and Byung-Hyun Park* PAK4 inhibition protects against liver ischemia/reperfusion injury: Role of Nrf2 phosphorylation. Hepatology 76(2):345-356 (2022).
5. Ui-Jin Bae, Byung-Hyun Park, Min Kyung Cho*, and Eun Ju Bae* Therapeutic effect of Acer tegmentosum Maxim twig extract in bile duct ligation–induced acute cholestasis in mice. J. Med. Food 25(6):652-659 (2022).
6. Hyun-Woo Kim, Ga-Hee Ryoo, Hyun-Young Jang, So-Young Rah, Dong Hyun Lee, Do-Kyun Kim, Eun Ju Bae*, and Byung-Hyun Park* NAD(+)-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice. Theranostics 12(7):3316-3328 (2022).
7. Ui-Jin Bae, Jae-Ha Ryu, Byung-Hyun Park*, and Eun Ju Bae* Angelica keiskei attenuates bile duct ligation–induced liver injury in mice. J. Med. Food 25(4):435-442 (2022).
8. Mi-Young Song, Chang Yeob Han, Young Jae Moon, Ju-Hyung Lee, Eun Ju Bae*, and Byung-Hyun Park* Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression. Nat. Commun. 13:1808 (2022).
9. Hyun-Young Jang, Do Hyun Ha, So Young Rah, Dong Hyun Lee, Sang-Myeong Lee*, and Byung-Hyun Park* Sirtuin 6 is a negative regulator of FcεRI signaling and anaphylactic responses. J. Allergy Clin. Immunol. 149(1):156-167 (2022).
2021
1. Yuancheng Mao, Chang Yeob Han, Lihua Hao, In Hyuk Bang, Eun Ju Bae*, and Byung-Hyun Park* p21-activated kinase 4 phosphorylates peroxisome proliferator-activated receptor γ and suppresses skeletal muscle regeneration. J. Cachexia Sarcopenia Muscle 12(6):1776-1788 (2021).
2. Lihua Hao, Yuancheng Mao, Jin Park, Eun Ju Bae*, and Byung-Hyun Park* Repurposing anthelmintic praziquantel to treat psoriasis. Br. J. Pharmacol. 178(23):4726-4740 (2021).
3. Dandan Wu, In Hyuk Bang, Byung-Hyun Park*, and Eun Ju Bae* Loss of Sirt6 in adipocytes impairs the ability of adipose tissue to adapt to intermittent fasting. Exp. Mol. Med. 53:1298-1306 (2021).
4. In Hyuk Bang, Dami Park, Youngyi Lee, Hwangeui Cho, Byung-Hyun Park*, and Eun Ju Bae* Sirtuin 6 promotes eosinophil differentiation by activating GATA-1 transcription factor. Aging Cell 20:e13418 (2021).
5. Mi-Ra Oh, Hui-Yeon Jang, Si-Yeon Lee, Su-Jin Jeong, Soo-Wan Chae, Seung-Ok Lee*, and Byung-Hyun Park* Lactobacillus plantarum HAC01 supplementation improves glycemic control in prediabetic subjects: A randomized, double-blind, placebo-controlled trial. Nutrients 13:2337 (2021).
6. Lihua Hao, Yuancheng Mao, Jin Park, Byoung-Mog Kwon, Eun Ju Bae*, and Byung-Hyun Park* 2′-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice. Exp. Mol. Med. 53(5):875-884 (2021).
7. Su-Jin Jung, Ji-Hyun Hwang, Eun-Ock Park, Seung-Ok Lee, Yun-Jo Chung, Myung-Jun Chung, Sang-Hyun Lim, Tae-Joong Lim, Yun-Hui Ha, Byung-Hyun Park* and Soo-Wan Chae* Regulation of alcohol and acetaldehyde metabolism by a mixture of Lactobacillus and Bifidobacterium species in human. Nutrients 13:1875 (2021).
8. Lihua Hao, Jin Park, Hyun-Young Jang, Eun Ju Bae, and Byung-Hyun Park Inhibiting protein kinase activity of pyruvate kinase M2 by SIRT2 deacetylase attenuates psoriasis. J. Invest. Dermatol. 141(2):355-363 (2021).
9. Chang Hun Lee, Yunjung Choi, Hyewon Cho, In Hyuk Bang, Lihua Hao, Seung-Ok Lee, Raok Jeon*, Eun Ju Bae*, and Byung-Hyun Park* Histone deacetylase 8 inhibition alleviates cholestatic liver injury and fibrosis. Biochem. Pharmacol. 183:114312 (2021).
2020
1. Ga-Hee Ryoo, Young Jae Moon, Sunghee Choi, Eun Ju Bae, Jae-Ha Ryu*, and Byung-Hyun Park* Tussilagone promotes osteoclast apoptosis and prevents estrogen deficiency-induced osteoporosis in mice. Biochem. Biophys. Res. Commun. 531: 508-514 (2020).
2. Min Yan Shi, In Hyuk Bang, Chang Yeob Han, Dae Ho Lee, Byung-Hyun Park*, and Eun Ju Bae* Statin suppresses sirtuin 6 through miR-495, increasing FoxO1-dependent hepatic gluconeogenesis. Theranostics 10(25): 11416-11427 (2020).
3. Lihua Hao, In Hyuk Bang, Jie Wang, Yuancheng Mao, Soon-Young Na, Jae Do Yang, Jeong Kon Seo, Hueng-Sik Choi, Eun Ju Bae*, and Byung-Hyun Park* ERRγ suppression by Sirt6 alleviates cholestatic liver injury and fibrosis. JCI Insight. 5(17):137566 (2020).
4. Eun-Soo Jung, Eun-Kyung Choi, Byung-Hyun Park*, and Soo-Wan Chae* Serum follicle-stimulating hormone levels are associated with cardiometabolic risk factors in postmenopausal Korean women. J. Clin. Med. 9:1161 (2020).
5. Eun-Ock Park, Eun-Ju Bae, Byung-Hyun Park*, and Soo-Wan Chae* The associations between liver enzymes and cardiovascular risk factors in adults with mild dyslipidemia. J. Clin. Med. 9:1147 (2020).
6. Mi-Ra Oh, Su-Jin Jung, Eun-Ju Bae, Byung-Hyun Park*, and Soo-Wan Chae* Clinical characteristics and associated risk factors of prediabetes in the southwestern region of Korea from 2010–2019. J. Clin. Med. 9:1114 (2020).
2019
1. Young Jae Moon, Zhongkai Zhang, In Hyuk Bang, Oh Kwang Kwon, Sun-Jung Yoon, Jung Ryul Kim, Sangkyu Lee, Eun Ju Bae*, and Byung-Hyun Park* Sirtuin 6 in preosteoclasts suppresses age-and estrogen deficiency-related bone loss through estrogen receptor α stabilization. Cell Death Differ. 26(11):2358-2370 (2019).
2. In Hyuk Bang, Oh Kwang Kwon, Lihua Hao, Dami Park, Myung-Ja Chung, Byung-Chul Oh, Sangkyu Lee, Eun Ju Bae*, and Byung-Hyun Park* Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis. Exp. Mol. Med. 51(9):107 (2019).
3. Mi-Young Song, Sang Hoon Kim, Ga-Hee Ryoo, Mi-Kyung Kim, Hye-Na Cha, So-Young Park, Hong Pil Hwang, Hee Chul Yu, Eun Ju Bae*, and Byung-Hyun Park* Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans. Exp. Mol. Med. 51(5):56 (2019).
4. Jeung-Hyun Koo, Hyun-Young Jang, Youngyi Lee, Young Jae Moon, Eun Ju Bae, Seok-Kweon Yun*, and Byung-Hyun Park* Myeloid cell-specific sirtuin 6 deficiency delays wound healing in mice by modulating inflammation and macrophage phenotypes. Exp. Mol. Med. 51(4):48 (2019).
5. Sang Hoon Kim, Zhongkai Zhang, Young Jae Moon, Il Woon Park, Yong Gon Cho, Raok Jeon*, and Byung-Hyun Park* SPA0355 prevents ovariectomy-induced bone loss in mice. Kor. J. Physiol. Pharmacol. 23(1): 47-54 (2019).
2018
1. Seong Ji Woo, Hae Sook Noh, Yun-Hong Cheon, Sang Mi Yi, Jin Ho Park, Eun Ju Bae, Sang-Il Lee*, and Byung-Hyun Park* Myeloid sirtuin 6 deficiency accelerates experimental and human rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium. EBioMedicine 38:228-237 (2018).
2. Ui-Jin Bae, Eun-Ock Park, John Park, Su-Jin Jung, Hyeonmi Ham, Kee-Won Yu, Young-Jun Park, Soo-Wan Chae*, and Byung-Hyun Park* Gypenoside UL4-rich Gynostemma pentaphyllum extract exerts a hepatoprotective effect on diet-induced nonalcoholic fatty liver disease. Am. J. Chinese Med. 46(6):1315-1332 (2018).
3. Ui-Jin Bae, Eun-Soo Jung, Su-Jin Jung, Soo-Wan Chae, and Byung-Hyun Park Mulberry leaf extract displays antidiabetic activity in db/db mice via Akt and AMP-activated protein kinase phosphorylation. Food & Nutrition Res. 62:1473 (2018).
4. Hyun-Young Jang, Jeung-Hyun Koo, Sang-Myeong Lee, and Byung-Hyun Park* Atopic dermatitis-like skin lesions are suppressed in fat-1 transgenic mice through the inhibition of inflammasomes. Exp. Mol. Med. 50:73 (2018).
5. Ui-Jin Bae, John Park, Il Woon Park, Byung Min Chae, Mi-Ra Oh, Su-Jin Jung, Geon-Seek Ryu, Soo-Wan Chae, and Byung-Hyun Park Epigallocatechin-3-gallate-rich green tea extract ameliorates fatty liver and weight gain in mice fed a high fat diet by activating the sirtuin 1 and AMP activating protein kinase pathway. Am. J. Chinese Med. 46(3):617-632 (2018).
2017
1. Youngyi Lee, Sun-O Ka, Hye-Na Cha, Yu-Na Chae, Mi-Kyung Kim, So-Young Park, Eun Ju Bae*, and Byung-Hyun Park* Myeloid sirtuin 6 deficiency causes insulin resistance in high-fat diet-fed mice by eliciting macrophage polarization toward an M1 phenotype. Diabetes 66(10):2659-2668 (2017).
2. Sun-O Ka, In Hyuk Bang, Eun Ju Bae*, and Byung-Hyun Park* Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by upregulation of Bach1, an Nrf2 repressor. FASEB J 31(9):3999-4010 (2017)
3. Ui-Jin Bae, Mi-Ra Oh, Tae-Sung Jung, Soo-Wan Chae, and Byung-Hyun Park Decursin and decursinol angelate-rich Angelica gigas Nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat diet. J. Funct. Foods 31:208-216 (2017).
4. Ui-Jin Bae, Mi-Ra Oh, Joon Park, Jong-Sang Park, Soo-Wan Chae, Baik Hwan Cho, and Byung-Hyun Park Supplementation with Lycium chinense fruit extract attenuates methionine choline deficient diet-induced steatohepatitis in mice. J. Funct. Foods 31:1-8 (2017).
5. Zheng Wang, Sun-O Ka, Youngyi Lee, Byung-Hyun Park, and Eun Ju Bae Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high-fat diet induced adipose hypertrophy in mice. Eur. J. Pharmacol. 799:201-210 (2017).
6. Jie Wang, Hyung-Won Koh, Lu Zhou, Ui-Jin Bae, Hwa-Suk Lee, In Hyuk Bang, Sun-O Ka, Seon-Hee Oh, Eun Ju Bae, and Byung-Hyun Park Sirtuin 2 aggravates post-ischemic liver injury by deacetylating mitogen activated protein kinase phosphatase-1. Hepatology 65(1):225-236 (2017).